For space considerations, the other (non-Russian) worldly destinations that have lost their Lufthansa patronage since 2012 have been cordoned into this separate post. There are three continents hosting less Lufthansa than before, but the only mainline European city that is out is tiny Trondheim, Norway (a first for the Timetablist here), which was curiously served once a week by an aging B737-400.
Asia has been particularly affected: the long-haul connections to Jakarta (via Singapore) and Kuala Lumpur (via Bangkok) could consistently work. More recently, Lufthansa has lost out to the Gulf three, and curtailed its dedicated flight to Abu Dhabi, and truncated the Muscat extension of its Frankfurt-Riyadh flights (although LX243, the Zürich-Dubai-Muscat connection on SWISS listed here, still operates today).
More dire but less surprising are the loss of further African services: no news that Tripoli has been abandoned, and Pointe-Noire's petrol-club PrivatAir B737-800 service via Libreville had its run, but less happy the abandonment of once-promising Asmara and long-served Khartoum, surely and sadly uneconomic nowadays. Also, lamentably, Caracas has likewise sunk into a less-viable abyss and receives fewer and fewer international airlines. Lufthansa closed down its Venezuelan outpost in May this year.